Endocrine Abstracts

Objective: To evaluate the role of thyroid blod flow assessment by color-flow Doppler ultrasonography in the differential diagnosis of thyrotoxicosis in an outpatient endocrinology clinic.Material and methods: Consecutive patients with thyrotoxicosis presenting to our center between January–December 2013 were included in the study. Clinical date were collected and measurements of TSH, serum free thyroxine and TSH receptor antibodies were performed. ...

The FGF signalling pathway regulates cell proliferation, differentiation, migration and cell specification in mutliple developing and adult tissues. It has also been implicated in tumor development and progression with a significant role in the cancer pathobiology of several malignant tumors including melanoma, breast, pancreas, head and neck and non-small lung cell cancer. FGF signalling plays a major role in the postnatal hypothalamic-pituitary (HP) axis, with dysregulation ...

Objective: We investigated the clinical usefulness of thyroid blood flow measurement by colour-flow Doppler ultrasonography in predicting relapse of Graves’ disease (GD).Patients and methods: In 30 euthyroid GD patients, (eight males and 23 females), aged 17–68 years (mean 43.8±12.8), after at least 1 year of treatment with anti-thyroid drug (ATD) and just before its withdrawal, we evaluate with colour-flow Doppler ultrasonography the colo...

Introduction: Hyperaldosteronism usually presents with hypertension and hypokalemia; however, there is recent evidence of a relationship with the parathyroid hormone. There are different theories to try to explain this relationship. Hyperaldosteronism treatment is medical or surgical depending upon etiology. We present three cases in which treatment solely for hyperaldosteronism also cured hyperparathyroidism.Materials and methods: We report three patien...

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours, which arise from neural crest (NC)-derived structures: the adrenal medulla and the paraganglia. Around one third of PPGLs are associated with inherited cancer susceptibility genes, the highest rate among all tumour types. Currently, the only diagnostic criterion for malignant disease is the presence of metastasis and no molecular or histological features have been identified that help predict risk. A...

Introduction: Obesity is one of the most prevalent health problems in our society. The marketing of Liraglutide and the Naltrexone/Bupropion combination has been given the green light.Objectives: To analyze the differences in a series of 19 patients assigned to treatment with Liraglutide or Naltrexone/Bupropion.Material and methods: A descriptive analysis was carried out using Stata. 19 patients were included, 9 were treated with L...

Background and Objective: Semaglutide, a glucagon-like peptide 1 (GLP1a) receptor agonist, reduces the risk of major adverse cardiovascular events in patients with type 2 diabetes mellitus (DM2). An oral version of semaglutide is now available, and patients may prefer it to the subcutaneous form. Our objective was to compare the effectiveness and safety of both formulations in real life.Methods: Retrospective real-world efficacy analysis including aGLP1-...